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Abstract -  Infra-Low Frequency Neurofeedback impinges on brain-based dysfunctions quite comprehensively, but the resulting improvements in self-regulatory competence cannot typically be captured both quantitatively and unambiguously. A measurable functional challenge is called for, and the Continuous Performance Test (CPT) offers such a challenge, one that both tests critical neuro-regulatory functions and has the benefit of broad acceptance within the neuropsychological community. A concise appraisal of results from a large database, one that extends over more than a decade and over thousands of clinical offices, is offered here as supportive testimony to the clinical effectiveness and practical utility of ILF neurofeedback in application to a wide variety of clinical conditions.